Oral doses up to 5000mg/kg in rats (approximately 1300 times the recommended human dose based on body surface area) and mice (about 675.7 times the recommended human dose based on body surface area) did not produce deaths or any clinical signs. Lansoprazole is not removed from the circulation by hemodialysis. In one reported case of overdose, the patient consumed 600mg of lansoprazole with no adverse reaction.
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